Establishing a Biobank of Colorectal and Pancreatic Cancer Models for the Pursuit of Personalised Therapies Investigating Pancreatic Lesions
Prof Peter Gibbs
Aim:
- To establish a living biobank of organoid cultures from patient-derived pancreatic cancer and normal tissue
- To establish a living biobank of patient-derived xenograft lines from patient-derived pancreatic cancer tissue
- To explore the use of organoid cultures to improve treatment selection, drug development, and/or determine new drug combinations to treat pancreatic cancer
Colorectal organoid
Courtesy of Yumiko Hirokawa, Sieber Laboratory
Status: Currently recruiting
Sites:
St Vincent’s Health, St Vincent’s Private Hospital, Melbourne Health, Northern Health, Cabrini Health, Peter Mac Callum Cancer Centre Epworth HealthCare, Austin Health, Monash Health, Warringal Private, Melbourne Private Hospital , Western Health
Ethics: HREC/16/MH/271
Principal Investigator:
Professor Peter Gibbs, The Walter and Eliza Hall Institute of Medical Research
Mr Brett Knowles, St Vincent’s Health, Epworth HealthCare, Melbourne Health
Eligibility
Inclusion
Adults ≥18 years of age
Have a clinical suspicion and/or tissue diagnosis of pancreatic cancer
Able to provide samples of tumor and/or normal tissue and blood and/or plasma samples
Exclusion
Unable to provide own consent
Outcome Measures
Successful establishment of patient derived tumour organoids ( PDTO)
Development of an assay test on PDTO using common chemotherapeutic agents
Genomic sequencing of pancreatic tumour samples and patient derived tumour organoids